FRANKFORT, Ky. (AP) — Placing much of the blame on smoking, a study chronicling the ongoing health crisis in Appalachia has concluded that the 13-state region suffers from a growing disparity in infant mortality and life expectancy, two key indicators of "a nation's health and well-being."

The study , published in the August issue of Health Affairs, compared infant mortality and life expectancy rates in Appalachia with the rest of the United States between 1990 and 2013. It found while the rates were similar in the 1990s, by 2013 infant mortality across Appalachia was 16 percent higher than th...