TEHRAN, Iran (AP) — Iran warned Tuesday that new U.S. sanctions targeting its supreme leader and other top officials meant "closing the doors of diplomacy" between Tehran and Washington amid heightened tensions, even as President Hassan Rouhani derided the White House as being "afflicted by mental retardation."

President Donald Trump called that a "very ignorant and insulting statement," tweeting that an Iranian attack on any U.S. interest will be met with "great and overwhelming force ... overwhelming will mean obliteration." His secretary of state said the Iranian statement was "immature."

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