DENVER (AP) — Despite federal opposition, Denver is trying again to become what could be the first U.S. city to open a supervised drug injection site, a strategy that some liberal cities have tried repeatedly to launch to reduce overdose deaths fueled by a nationwide opioid epidemic.

The Denver City Council voted 12-1 on Monday to approve a measure that would allow one site to open for at least two years under a pilot program. But there are still several hurdles to clear.

The program must win approval from the state Legislature, which is now under Democratic control after this month's election...