GAZA CITY, Gaza Strip (AP) — Palestinian militants fired dozens of rockets from the Gaza Strip into southern Israel on Wednesday, in a first response to Israeli airstrikes that have killed 16 Palestinians, including three senior militants and at least 10 civilians.

The rocket fire set off air-raid sirens throughout southern Israel, where residents had been bracing for an attack since Israel carried out its first airstrikes early Tueday.

As air raid sirens continued to wail, the army said at least 60 rockets had been fired in less than an hour. There were no immediate reports of damage or injuries.

Earlier Wednesday, Israeli aircraft struck targets in Gaza a second straight day, killing at least one Palestinian and pushing the region closer toward a new round of heavy fighting.

Tuesday's strikes killed three senior Islamic Jihad militants and at least 10 civilians — most of them women and children. Palestinian militants have pledged to retaliate while Israel says it is prepared for a further escalation of hostilities.

The Israeli military said its attacks were focused on Palestinian Islamic Jihad militant infrastructure in the coastal enclave.

The army said one airstrike targeted militants traveling to a rocket launcher site in the southern Gaza Strip. Later, the army said warplanes struck suspected rocket and mortar launching sites.

Medics said the first strike killed one man and seriously wounded another. Palestinian officials could not confirm whether the men were militants.

It also remained unclear whether two Palestinians killed in a separate airstrike late Tuesday were militants or civilians. Israel has claimed the men were preparing to fire anti-tank missiles.

The Israeli military had instructed residents of southern Israel to remain near bomb shelters, and schools were still closed for a second day as a precaution against rocket attacks.

Israel says the airstrikes are a response to a barrage of rocket fire launched last week by Islamic Jihad in response to the death of one of its members from a hunger strike while in Israeli custody.

Israel says it is trying to avoid conflict with Hamas, the more powerful militant group that rules Gaza, and confine the fighting to Islamic Jihad.

"Our actions are meant to prevent further escalation," said Rear Adm. Danny Hagari, the Israeli military's chief spokesman. "Israel is not interested in war."

But Hamas has expressed solidarity with its smaller counterpart, and the two groups often coordinate with one another.

If the violence continues, the risk of a full-blown war could increase. Israel and Hamas have fought four wars since the Islamic group, which opposes Israel's existence, took control of Gaza in 2007.

Earlier on Wednesday, the military said that Palestinian gunmen opened fire at troops in the Palestinian town of Qabatiya in the northern West Bank during an army raid. Troops returned fire, killing the two men, and confiscated their firearms, it said.

The Palestinian Health Ministry identified the slain men as Ahmed Assaf, 19, and Rani Qatanat, 24. The Islamic Jihad militant group later claimed the two men as its members.

Israel has been conducting near-daily military raids in the occupied West Bank for over a year to detain suspected Palestinian militants, including many from Islamic Jihad. The northern West Bank city of Jenin and its environs have been the frequent target of such raids as it has emerged as a hub of Palestinian militant activity.

Israel says the raids in the West Bank are meant to dismantle militant networks and thwart future attacks.

At least 107 Palestinians, around half of them militants, have been killed by Israeli fire in the occupied West Bank since the start of 2023, according to an Associated Press tally. At least 20 people have been killed in Palestinian attacks targeting Israelis.

Israel captured the West Bank. east Jerusalem and Gaza in the 1967 Mideast war. The Palestinians seek all three areas for a future state.